FMO-guided design of darunavir analogs as HIV-1 protease inhibitors

Abstract The prevalence of HIV-1 infection continues to pose a significant global public health issue, highlighting the need for antiretroviral drugs that target viral proteins to reduce viral replication. One such target is HIV-1 protease (PR), responsible for cleaving viral polyproteins, leading t...

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Bibliographic Details
Main Authors: Hathaichanok Chuntakaruk, Kowit Hengphasatporn, Yasuteru Shigeta, Chanat Aonbangkhen, Vannajan Sanghiran Lee, Tanatorn Khotavivattana, Thanyada Rungrotmongkol, Supot Hannongbua
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-024-53940-1