Transcriptional Repression of p53 by PAX3 Contributes to Gliomagenesis and Differentiation of Glioma Stem Cells

Transcriptional Repression of p53 by PAX3 Contributes to Gliomagenesis and Differentiation of Glioma Stem Cells

Although there are available therapies as surgery, chemotherapy and radiation, glioblastoma (GBM) still has been considered as the most common and overwhelming primary tumor of brain. In GBM, the brain glioma stem cells (BGSCs) were identified and played a crucial role in resistance of GBM to conven...

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Bibliographic Details
Main Authors: Hui Zhu, Hongkui Wang, Qingfeng Huang, Qianqian Liu, Yibing Guo, Jingjing Lu, Xiaohong Li, Chengbin Xue, Qianqian Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
PAX3
p53
glioma
stem cells
tumor microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00187/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00187/full

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