Anthrax Lethal Toxin-Mediated Disruption of Endothelial VE-Cadherin Is Attenuated by Inhibition of the Rho-Associated Kinase Pathway

Anthrax Lethal Toxin-Mediated Disruption of Endothelial VE-Cadherin Is Attenuated by Inhibition of the Rho-Associated Kinase Pathway

Systemic anthrax disease is characterized by vascular leakage pathologies. We previously reported that anthrax lethal toxin (LT) induces human endothelial barrier dysfunction in a cell death-independent manner with actin stress fiber formation and disruption of adherens junctions (AJs). In the prese...

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Bibliographic Details
Main Authors: Jason M. Warfel, Felice D’Agnillo
Format: Article
Language:English
Published: MDPI AG 2011-10-01
Series:Toxins
Subjects:
anthrax lethal toxin
vascular endothelium
adherens junction
barrier function
cadherin
actin stress fibers
Online Access:http://www.mdpi.com/2072-6651/3/10/1278/

Internet

http://www.mdpi.com/2072-6651/3/10/1278/

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