Elucidation of the binding mechanism of astragaloside IV derivative with human serum albumin and its cardiotoxicity in zebrafish embryos

Elucidation of the binding mechanism of astragaloside IV derivative with human serum albumin and its cardiotoxicity in zebrafish embryos

LS-102 is a new derivative of astragaloside IV (AGS IV) that has been shown to possess potentially significant cardioprotective effects. However, there are no reports concerning its interaction with human serum albumin (HSA) and toxicology in vertebrates. The present investigation was undertaken to...

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Bibliographic Details
Main Authors: You-Jiao Wu, Zhan-Hua Li, Jiu-Yan Li, Yan Zhou, Run-Yue Wang, Xiao-Yi Chen, Lin-Sen Qing, Pei Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
astragaloside IV derivative
drug-HSA interaction
equilibrium dialysis
UHPLC-MS/MS
molecular modeling
zebrafish
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.987882/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.987882/full

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