High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniaeResearch in context

High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniaeResearch in context

Summary: Background: The current pipeline for new antibiotics fails to fully address the significant threat posed by drug-resistant Gram-negative bacteria that have been identified by the World Health Organization (WHO) as a global health priority. New antibacterials acting through novel mechanisms...

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Bibliographic Details
Main Authors: Benjamin Blasco, Soojin Jang, Hiroki Terauchi, Naoki Kobayashi, Shuichi Suzuki, Yuichiro Akao, Atsuko Ochida, Nao Morishita, Terufumi Takagi, Hiroyuki Nagamiya, Yamato Suzuki, Toshiaki Watanabe, Hyunjung Lee, Sol Lee, David Shum, Ahreum Cho, Dahae Koh, Soonju Park, Honggun Lee, Kideok Kim, Henni-Karoliina Ropponen, Renata Maria Augusto da Costa, Steven Dunn, Sunil Ghosh, Peter Sjö, Laura J.V. Piddock
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:EBioMedicine
Subjects:
Multidrug-resistance
Acinetobacter baumannii
Klebsiella pneumoniae
Antibacterial drug discovery
High-throughput screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424001087

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http://www.sciencedirect.com/science/article/pii/S2352396424001087

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