Co-delivery of rhBMP-2 and zoledronic acid using calcium sulfate/hydroxyapatite carrier as a bioactive bone substitute to enhance and accelerate spinal fusion

Co-delivery of rhBMP-2 and zoledronic acid using calcium sulfate/hydroxyapatite carrier as a bioactive bone substitute to enhance and accelerate spinal fusion

Recombinant human bone morphogenetic protein-2 (rhBMP-2) has been FDA-approved for lumbar fusion, but supraphysiologic initial burst release due to suboptimal carrier and late excess bone resorption caused by osteoclast activation have limited its clinical usage. One strategy to mitigate the pro-ost...

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Bibliographic Details
Main Authors: Xinggui Tian, Corina Vater, Deepak Bushan Raina, Lisa Findeisen, Lucas-Maximilian Matuszewski, Magnus Tägil, Lars Lidgren, Anja Winkler, Robert Gottwald, Niels Modler, Klaus-Dieter Schaser, Alexander C. Disch, Stefan Zwingenberger
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-06-01
Series:Bioactive Materials
Subjects:
Calcium sulfate/hydroxyapatite
Bone morphogenetic protein 2
Bisphosphonate
Spinal fusion
Bone substitute
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24000793

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http://www.sciencedirect.com/science/article/pii/S2452199X24000793

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