Cryo-EM Structures of Two Bacteriophage Portal Proteins Provide Insights for Antimicrobial Phage Engineering

Cryo-EM Structures of Two Bacteriophage Portal Proteins Provide Insights for Antimicrobial Phage Engineering

Widespread antibiotic resistance has returned attention to bacteriophages as a means of managing bacterial pathogenesis. Synthetic biology approaches to engineer phages have demonstrated genomic editing to broaden natural host ranges, or to optimise microbicidal action. Gram positive pathogens cause...

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Bibliographic Details
Main Authors: Abid Javed, Hugo Villanueva, Shadikejiang Shataer, Sara Vasciaveo, Renos Savva, Elena V. Orlova
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
bacteriophage
GA1
phiCPV4
portal protein
cryo electron microscopy
structural analysis
Online Access:https://www.mdpi.com/1999-4915/13/12/2532

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https://www.mdpi.com/1999-4915/13/12/2532

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