Targeted CRM197-PEG-PEI/siRNA Complexes for Therapeutic RNAi in Glioblastoma

Targeted CRM197-PEG-PEI/siRNA Complexes for Therapeutic RNAi in Glioblastoma

RNA interference (RNAi) allows the specific knockdown of tumor relevant genes. To induce RNAi, the delivery of small interfering RNAs (siRNAs) is of crucial importance. This is particularly challenging for their therapeutic applications in vivo. Low molecular weight branched polyethylenimine (PEI) i...

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Bibliographic Details
Main Authors: Achim Aigner, Chantal C.M. Appeldoorn, Sabrina Höbel, Pieter J. Gaillard
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:Pharmaceuticals
Subjects:
siRNA
RNA interference
RNAi
CRM197
HB-EGF
polyethylenimine
PEI
targeted delivery
pleiotrophin
glioblastoma
therapeutic siRNA delivery
Online Access:http://www.mdpi.com/1424-8247/4/12/1591/

Internet

http://www.mdpi.com/1424-8247/4/12/1591/

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