The Mechanism of Action of Biguanides: New Answers to a Complex Question

Biguanides are a family of antidiabetic drugs with documented anticancer properties in preclinical and clinical settings. Despite intensive investigation, how they exert their therapeutic effects is still debated. Many studies support the hypothesis that biguanides inhibit mitochondrial complex I, i...

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Bibliographic Details
Main Authors: Laura Di Magno, Fiorella Di Pastena, Rosa Bordone, Sonia Coni, Gianluca Canettieri
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/14/13/3220