Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma

Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma

Background Immune responses against tumors are subject to negative feedback regulation. Immune checkpoint inhibitors (ICIs) blocking Programmed cell death protein 1 (PD-1), a receptor expressed on T cells, or its ligand PD-L1 have significantly improved the treatment of cancer, in particular maligna...

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Bibliographic Details
Main Authors: Antje Sucker, Iris Helfrich, Luiza Martins Nascentes Melo, Dayana Herrera-Rios, Daniel Hinze, Stefanie Löffek, Irem Oezel, Juliane Klein, Sonia Leonardelli, Isa-Vanessa Westedt, Yahya Al-Matary, Sara Egea-Rodriguez, Alexandra Brenzel, Maja Bau, Eva Hadaschik, Florian Wirsdörfer, Niklas Uhlenbrock, Daniel Rauh, Joanna Poźniak, Florian Rambow, Jean-Christophe Marine, Maike Effern, Nicole Glodde, Jadwiga Jablonska
Format: Article
Language:English
Published: BMJ Publishing Group 2023-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/11/4/e004150.full

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https://jitc.bmj.com/content/11/4/e004150.full

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