Targeting NMDA receptors in neuropsychiatric disorders by drug screening on human neurons derived from pluripotent stem cells

Abstract NMDA receptors (NMDARs), a prominent subtype of glutamatergic receptors, are implicated in the pathogenesis and development of neuropsychiatric disorders such as epilepsy, intellectual disability, autism spectrum disorder, and schizophrenia, and are therefore a potential therapeutic target...

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Bibliographic Details
Main Authors: Wenbo Zhang, P. Joel Ross, James Ellis, Michael W. Salter
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-02010-z