Mitogen-activated protein kinase eight polymorphisms are associated with immune responsiveness to HBV vaccinations in infants of HBsAg(+)/HBeAg(−) mothers
Abstract Background Infants born to hepatitis B surface antigen (HBsAg) positive mothers are at a higher risk for Hepatitis B virus (HBV) infection. Host genetic background plays an important role in determining the strength of immune response to vaccination. We conducted this study to investigate t...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-06-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-018-3166-x |
| _version_ | 1818260093705125888 |
|---|---|
| author | Meng Zhuo Cao Yan Hua Wu Si Min Wen Yu Chen Pan Chong Wang Fei Kong Chuan Wang Jun Qi Niu Jie Li Jing Jiang |
| author_facet | Meng Zhuo Cao Yan Hua Wu Si Min Wen Yu Chen Pan Chong Wang Fei Kong Chuan Wang Jun Qi Niu Jie Li Jing Jiang |
| author_sort | Meng Zhuo Cao |
| collection | DOAJ |
| description | Abstract Background Infants born to hepatitis B surface antigen (HBsAg) positive mothers are at a higher risk for Hepatitis B virus (HBV) infection. Host genetic background plays an important role in determining the strength of immune response to vaccination. We conducted this study to investigate the association between Tumor necrosis factor (TNF) and Mitogen-activated protein kinase eight (MAPK8) polymorphisms and low response to hepatitis B vaccines. Methods A total of 753 infants of HBsAg positive and hepatitis Be antigen (HBeAg) negative mothers from the prevention of mother-to-infant transmission of HBV cohort were included. Five tag single nucleotide polymorphism (SNPs) (rs1799964, rs1800629, rs3093671, rs769177 and rs769178) in TNF and two tag SNPs (rs17780725 and rs3827680) in MAPK8 were genotyped using the MassARRAY platform. Results A higher percentage of breastfeeding (P = 0.013) and a higher level of Ab titers were observed in high responders (P < 0.001). The MAPK8 rs17780725 AA genotype increased the risk of low response to hepatitis B vaccines (OR = 3.176, 95% CI: 1.137–8.869). Additionally, subjects with the AA genotype may have a lower Ab titer than subjects with GA or GG genotypes (P = 0.051). Compared to infants who were breastfed, infants who were not breastfed had an increased risk of low response to hepatitis B vaccine (OR = 2.901, 95% CI:1.306–6.441). Conclusions MAPK8 polymorphisms are associated with immune response to HBV vaccinations in infants of HBsAg(+)/HBeAg(−) mothers. |
| first_indexed | 2024-12-12T18:25:51Z |
| format | Article |
| id | doaj.art-eb0cfa5345f1470791098bcc7c7fc564 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-12T18:25:51Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-eb0cfa5345f1470791098bcc7c7fc5642022-12-22T00:16:01ZengBMCBMC Infectious Diseases1471-23342018-06-011811610.1186/s12879-018-3166-xMitogen-activated protein kinase eight polymorphisms are associated with immune responsiveness to HBV vaccinations in infants of HBsAg(+)/HBeAg(−) mothersMeng Zhuo Cao0Yan Hua Wu1Si Min Wen2Yu Chen Pan3Chong Wang4Fei Kong5Chuan Wang6Jun Qi Niu7Jie Li8Jing Jiang9Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science CenterDivision of Clinical Research, The First Hospital of Jilin UniversityDivision of Clinical Research, The First Hospital of Jilin UniversityDivision of Clinical Research, The First Hospital of Jilin UniversityDepartment of Hepatology, The First Hospital of Jilin UniversityDepartment of Hepatology, The First Hospital of Jilin UniversityDivision of Clinical Research, The First Hospital of Jilin UniversityDepartment of Hepatology, The First Hospital of Jilin UniversityDepartment of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science CenterDivision of Clinical Research, The First Hospital of Jilin UniversityAbstract Background Infants born to hepatitis B surface antigen (HBsAg) positive mothers are at a higher risk for Hepatitis B virus (HBV) infection. Host genetic background plays an important role in determining the strength of immune response to vaccination. We conducted this study to investigate the association between Tumor necrosis factor (TNF) and Mitogen-activated protein kinase eight (MAPK8) polymorphisms and low response to hepatitis B vaccines. Methods A total of 753 infants of HBsAg positive and hepatitis Be antigen (HBeAg) negative mothers from the prevention of mother-to-infant transmission of HBV cohort were included. Five tag single nucleotide polymorphism (SNPs) (rs1799964, rs1800629, rs3093671, rs769177 and rs769178) in TNF and two tag SNPs (rs17780725 and rs3827680) in MAPK8 were genotyped using the MassARRAY platform. Results A higher percentage of breastfeeding (P = 0.013) and a higher level of Ab titers were observed in high responders (P < 0.001). The MAPK8 rs17780725 AA genotype increased the risk of low response to hepatitis B vaccines (OR = 3.176, 95% CI: 1.137–8.869). Additionally, subjects with the AA genotype may have a lower Ab titer than subjects with GA or GG genotypes (P = 0.051). Compared to infants who were breastfed, infants who were not breastfed had an increased risk of low response to hepatitis B vaccine (OR = 2.901, 95% CI:1.306–6.441). Conclusions MAPK8 polymorphisms are associated with immune response to HBV vaccinations in infants of HBsAg(+)/HBeAg(−) mothers.http://link.springer.com/article/10.1186/s12879-018-3166-xHepatitis B vaccinationMAPK8TNFMother-to-infant transmissionLow response |
| spellingShingle | Meng Zhuo Cao Yan Hua Wu Si Min Wen Yu Chen Pan Chong Wang Fei Kong Chuan Wang Jun Qi Niu Jie Li Jing Jiang Mitogen-activated protein kinase eight polymorphisms are associated with immune responsiveness to HBV vaccinations in infants of HBsAg(+)/HBeAg(−) mothers BMC Infectious Diseases Hepatitis B vaccination MAPK8 TNF Mother-to-infant transmission Low response |
| title | Mitogen-activated protein kinase eight polymorphisms are associated with immune responsiveness to HBV vaccinations in infants of HBsAg(+)/HBeAg(−) mothers |
| title_full | Mitogen-activated protein kinase eight polymorphisms are associated with immune responsiveness to HBV vaccinations in infants of HBsAg(+)/HBeAg(−) mothers |
| title_fullStr | Mitogen-activated protein kinase eight polymorphisms are associated with immune responsiveness to HBV vaccinations in infants of HBsAg(+)/HBeAg(−) mothers |
| title_full_unstemmed | Mitogen-activated protein kinase eight polymorphisms are associated with immune responsiveness to HBV vaccinations in infants of HBsAg(+)/HBeAg(−) mothers |
| title_short | Mitogen-activated protein kinase eight polymorphisms are associated with immune responsiveness to HBV vaccinations in infants of HBsAg(+)/HBeAg(−) mothers |
| title_sort | mitogen activated protein kinase eight polymorphisms are associated with immune responsiveness to hbv vaccinations in infants of hbsag hbeag mothers |
| topic | Hepatitis B vaccination MAPK8 TNF Mother-to-infant transmission Low response |
| url | http://link.springer.com/article/10.1186/s12879-018-3166-x |
| work_keys_str_mv | AT mengzhuocao mitogenactivatedproteinkinaseeightpolymorphismsareassociatedwithimmuneresponsivenesstohbvvaccinationsininfantsofhbsaghbeagmothers AT yanhuawu mitogenactivatedproteinkinaseeightpolymorphismsareassociatedwithimmuneresponsivenesstohbvvaccinationsininfantsofhbsaghbeagmothers AT siminwen mitogenactivatedproteinkinaseeightpolymorphismsareassociatedwithimmuneresponsivenesstohbvvaccinationsininfantsofhbsaghbeagmothers AT yuchenpan mitogenactivatedproteinkinaseeightpolymorphismsareassociatedwithimmuneresponsivenesstohbvvaccinationsininfantsofhbsaghbeagmothers AT chongwang mitogenactivatedproteinkinaseeightpolymorphismsareassociatedwithimmuneresponsivenesstohbvvaccinationsininfantsofhbsaghbeagmothers AT feikong mitogenactivatedproteinkinaseeightpolymorphismsareassociatedwithimmuneresponsivenesstohbvvaccinationsininfantsofhbsaghbeagmothers AT chuanwang mitogenactivatedproteinkinaseeightpolymorphismsareassociatedwithimmuneresponsivenesstohbvvaccinationsininfantsofhbsaghbeagmothers AT junqiniu mitogenactivatedproteinkinaseeightpolymorphismsareassociatedwithimmuneresponsivenesstohbvvaccinationsininfantsofhbsaghbeagmothers AT jieli mitogenactivatedproteinkinaseeightpolymorphismsareassociatedwithimmuneresponsivenesstohbvvaccinationsininfantsofhbsaghbeagmothers AT jingjiang mitogenactivatedproteinkinaseeightpolymorphismsareassociatedwithimmuneresponsivenesstohbvvaccinationsininfantsofhbsaghbeagmothers |