Suppression of inflammation-induced lung cancer cells proliferation and metastasis by exiguaflavanone A and exiguaflavanone B from Sophora exigua root extract through NLRP3 inflammasome pathway inhibition

Suppression of inflammation-induced lung cancer cells proliferation and metastasis by exiguaflavanone A and exiguaflavanone B from Sophora exigua root extract through NLRP3 inflammasome pathway inhibition

Objective: Non-small cell lung cancer (NSCLC) is recognized for its aggressive nature and propensity for high rates of metastasis. The NLRP3 inflammasome pathway plays a vital role in the progression of NSCLC. This study aimed to investigate the effects of S. exigua extract and its active compounds...

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Bibliographic Details
Main Authors: Punnida Arjsri, Kamonwan Srisawad, Warathit Semmarath, Sonthaya Umsumarng, Lapamas Rueankham, Aroonchai Saiai, Methee Rungrojsakul, Trinnakorn Katekunlaphan, Songyot Anuchapreeda, Pornngarm Dejkriengkraikul
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
Sophora exigua
exiguaflavanone
non-small cell lung cancer
cancer progression and metastasis
NLRP3 inflammasome pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1243727/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1243727/full

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