Human Macrophages Polarized by Interaction with Apoptotic Cells Produce Fibrosis-Associated Mediators and Enhance Pro-Fibrotic Activity of Dermal Fibroblasts In Vitro

Apoptosis and subsequent removal of dead cells are an essential part of wound healing. Macrophages phagocytize apoptotic cells (efferocytosis) and contribute to the resolution of inflammation. However, their participation in fibrogenesis and the mechanisms of influence on this process remain unclear...

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Bibliographic Details
Main Authors: Aleksandra Maksimova, Ekaterina Shevela, Lyudmila Sakhno, Marina Tikhonova, Aleksandr Ostanin, Elena Chernykh
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/12/15/1928