DNA adducts as link between in vitro and in vivo carcinogenicity – A case study with benzo[a]pyrene

DNA adducts as link between in vitro and in vivo carcinogenicity – A case study with benzo[a]pyrene

To reduce the need for animal tests, in vitro assays are often used as alternative methods. To derive toxic doses for higher tier organisms from in vitro assay results, quantitative in vitro-in vivo extrapolation (qIVIVE) based on physiological-based toxicokinetic (PBTK) models is typically the pref...

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Bibliographic Details
Main Authors: Martin Gerhards, Alexander Böhme, Kristin Schubert, Bernhard Kodritsch, Nadin Ulrich
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Current Research in Toxicology
Subjects:
In vitro-in vivo extrapolation IVIVE
Benzo[a]pyrene
DNA adduct formation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X22000342

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http://www.sciencedirect.com/science/article/pii/S2666027X22000342

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