Synthesis and Preclinical Evaluation of Three Novel <sup>68</sup>Ga-Labeled Bispecific PSMA/FAP-Targeting Tracers for Prostate Cancer Imaging

Synthesis and Preclinical Evaluation of Three Novel <sup>68</sup>Ga-Labeled Bispecific PSMA/FAP-Targeting Tracers for Prostate Cancer Imaging

Tumor heterogeneity limits the efficacy and reliability of monospecific radiopharmaceuticals in prostate cancer diagnosis and therapy. To overcome this limitation and improve lesion detection sensitivity, we developed and evaluated three bispecific radiotracers that can target both prostate-specific...

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Bibliographic Details
Main Authors: Arsyangela Verena, Zhengxing Zhang, Hsiou-Ting Kuo, Helen Merkens, Jutta Zeisler, Ryan Wilson, Shreya Bendre, Antonio A. W. L. Wong, François Bénard, Kuo-Shyan Lin
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
prostate-specific membrane antigen
fibroblast activation protein
bispecific radiotracers
PET/CT
Gallium-68
Online Access:https://www.mdpi.com/1420-3049/28/3/1088

Internet

https://www.mdpi.com/1420-3049/28/3/1088

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