Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin

Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin

Abstract Background [18F]Fluoromisonidazole ([18F]FMISO) and 1-[18F]fluoro-3-((2-((1E,3E)-4-(6-(methylamino)pyridine-3-yl)buta-1,3-dien-1-yl)benzo[d]thiazol-6-yl)oxy)propan-2-ol ([18F]PM-PBB3 or [18F]APN-1607) are clinically used radiotracers for imaging hypoxia and tau pathology, respectively. Both...

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Bibliographic Details
Main Authors: Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Masayuki Fujinaga, Wakana Mori, Katsushi Kumata, Masayuki Hanyu, Kenji Furutsuka, Hiroki Hashimoto, Kazunori Kawamura, Ming-Rong Zhang
Format: Article
Language:English
Published: SpringerOpen 2021-07-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
18F
[18F]Epifluorohydrin
[18F]FMISO
[18F]PM-PBB3
Positron emission tomography (PET)
Online Access:https://doi.org/10.1186/s41181-021-00138-9

Internet

https://doi.org/10.1186/s41181-021-00138-9

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