Deletion of microRNA-183-96-182 Cluster in Lymphocytes Suppresses Anti-DsDNA Autoantibody Production and IgG Deposition in the Kidneys in C57BL/6-Faslpr/lpr Mice

Dysregulated miRNAs have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Our previous study reported a substantial increase in three miRNAs located at the miR-183-96-182 cluster (miR-183C) in several autoimmune lupus-prone mice, including MRL/lpr and C57BL/6-lpr (B6/lpr)....

Full description

Bibliographic Details
Main Authors: Zhuang Wang, Bettina Heid, Ran Lu, Mohit Sachdeva, Michael R. Edwards, JingJing Ren, Thomas E. Cecere, Deena Khan, Taschua Jeboda, David G. Kirsch, Christopher M. Reilly, Rujuan Dai, S. Ansar Ahmed
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.840060/full