Spreading of Isolated <i>Ptch</i> Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice

Spreading of Isolated <i>Ptch</i> Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice

Basal cell carcinoma (BCC) originate from Hedgehog/Patched signaling-activated epidermal stem cells. However, the chemically induced tumorigenesis of mice with a <i>CD4Cre</i>-mediated biallelic loss of the Hedgehog signaling repressor Patched also induces BCC formation. Here, we identif...

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Bibliographic Details
Main Authors: Nadine Brandes, Slavica Hristomanova Mitkovska, Dominik Simon Botermann, Wiebke Maurer, Anna Müllen, Hanna Scheile, Sebastian Zabel, Anke Frommhold, Ina Heß, Heidi Hahn, Anja Uhmann
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
Patched receptor
basal cell carcinoma
keratin 5
epidermal cells
epidermis
hair follicle
Online Access:https://www.mdpi.com/1422-0067/21/23/9295

Internet

https://www.mdpi.com/1422-0067/21/23/9295

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