Spreading of Isolated <i>Ptch</i> Mutant Basal Cell Carcinoma Precursors Is Physiologically Suppressed and Counteracts Tumor Formation in Mice
Basal cell carcinoma (BCC) originate from Hedgehog/Patched signaling-activated epidermal stem cells. However, the chemically induced tumorigenesis of mice with a <i>CD4Cre</i>-mediated biallelic loss of the Hedgehog signaling repressor Patched also induces BCC formation. Here, we identif...
Main Authors: | Nadine Brandes, Slavica Hristomanova Mitkovska, Dominik Simon Botermann, Wiebke Maurer, Anna Müllen, Hanna Scheile, Sebastian Zabel, Anke Frommhold, Ina Heß, Heidi Hahn, Anja Uhmann |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-12-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/23/9295 |
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