Blood-CSF barrier clearance of ABC transporter substrates is suppressed by interleukin-6 in lupus choroid plexus spheroids

Blood-CSF barrier clearance of ABC transporter substrates is suppressed by interleukin-6 in lupus choroid plexus spheroids

Abstract Background The choroid plexus (CP) has been recently implicated in the pathogenesis of the neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE). Lupus patients demonstrate increased serum and cerebrospinal fluid (CSF) concentrations of interleukin-6 (IL-6), which can disr...

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Bibliographic Details
Main Authors: Joshua A. Reynolds, Lola Torz, Leslie Cummins, Ariel D Stock, Ayal Ben-Zvi, Chaim Putterman
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Fluids and Barriers of the CNS
Subjects:
NPSLE
Cerebrospinal fluid
blood-CSF barrier
Interleukin-6
BCRP
MRP1
Online Access:https://doi.org/10.1186/s12987-025-00628-x

Internet

https://doi.org/10.1186/s12987-025-00628-x

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