Viable mouse gene ablations that robustly alter brain Aβ levels are rare

Viable mouse gene ablations that robustly alter brain Aβ levels are rare

<p>Abstract</p> <p>Background</p> <p>Accumulation of amyloid-β (Aβ) peptide in the brain is thought to play a key pathological role in Alzheimer's disease. Many pharmacological targets have therefore been proposed based upon the biochemistry of Aβ, but not all are...

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Bibliographic Details
Main Authors: Small Daniel L, Majumdar Antara, Corradi John, Barrezueta Nestor, Sankaranarayanan Sethu, Meredith Jere E, Guss Valerie, Thompson Mark W, Lin Xu-Alan, Toyn Jeremy H, Hansard Melissa, Lanthorn Thomas, Westphal Ryan S, Albright Charles F
Format: Article
Language:English
Published: BMC 2010-11-01
Series:BMC Neuroscience
Online Access:http://www.biomedcentral.com/1471-2202/11/143

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http://www.biomedcentral.com/1471-2202/11/143

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