High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain

High fat-fed GPR55 null mice display impaired glucose tolerance without concomitant changes in energy balance or insulin sensitivity but are less responsive to the effects of the cannabinoids rimonabant or Δ(9)-tetrahydrocannabivarin on weight gain

Background The insulin-sensitizing phytocannabinoid, Δ(9)-tetrahydrocannabivarin (THCV) can signal partly via G-protein coupled receptor-55 (GPR55 behaving as either an agonist or an antagonist depending on the assay). The cannabinoid receptor type 1 (CB1R) inverse agonist rimonabant is also a GPR55...

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Bibliographic Details
Main Authors: Edward T. Wargent, Malgorzata Kepczynska, Mohamed Sghaier Zaibi, David C. Hislop, Jonathan R.S. Arch, Claire J. Stocker
Format: Article
Language:English
Published: PeerJ Inc. 2020-08-01
Series:PeerJ
Subjects:
GPR55
THCV
Rimonabant
Diabetes
Obesity
Glucose tolerance
Online Access:https://peerj.com/articles/9811.pdf

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https://peerj.com/articles/9811.pdf

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