Single-cell sequencing of a novel model of neonatal bile duct ligation in mice identifies macrophage heterogeneity in obstructive cholestasis

Single-cell sequencing of a novel model of neonatal bile duct ligation in mice identifies macrophage heterogeneity in obstructive cholestasis

Abstract Macrophages (MΦ) play a role in neonatal etiologies of obstructive cholestasis, however, the role for precise MΦ subsets remains poorly defined. We developed a neonatal murine model of bile duct ligation (BDL) to characterize etiology-specific differences in neonatal cholestatic MΦ polariza...

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Bibliographic Details
Main Authors: Swati Antala, Kyle D. Gromer, Gaurav Gadhvi, Alyssa Kriegermeier, Jiao-Jing Wang, Hiam Abdala-Valencia, Joshua B. Wechsler, Harris Perlman, Deborah R. Winter, Zheng J. Zhang, Richard M. Green, Sarah A. Taylor
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-41207-0

Internet

https://doi.org/10.1038/s41598-023-41207-0

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