Enhanced osteoblastic differentiation of parietal bone in a novel murine model of mucopolysaccharidosis type II

Enhanced osteoblastic differentiation of parietal bone in a novel murine model of mucopolysaccharidosis type II

Mucopolysaccharidosis type II (MPS II, OMIM 309900) is an X-linked disorder caused by a deficiency of lysosomal enzyme iduronate-2-sulfatase (IDS). The clinical manifestations of MPS II involve cognitive decline, bone deformity, and visceral disorders. These manifestations are closely associated wit...

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Bibliographic Details
Main Authors: Narutoshi Yamazaki, Mari Ohira, Shuji Takada, Akira Ohtake, Masafumi Onodera, Mahito Nakanishi, Torayuki Okuyama, Ryuichi Mashima
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Mucopolysaccharidosis II
Hunter syndrome
Iduronate-2-sulfatase
Bone deformity
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426923000678

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http://www.sciencedirect.com/science/article/pii/S2214426923000678

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