Protein Formulations Containing Polysorbates: Are Metal Chelators Needed at All?

Proteins are prone to post-translational modifications at specific sites, which can affect their physicochemical properties, and consequently also their safety and efficacy. Sources of post-translational modifications include oxygen and reactive oxygen species. Additionally, catalytic amounts of Fe(...

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Bibliographic Details
Main Authors: Ema Valentina Brovč, Stane Pajk, Roman Šink, Janez Mravljak
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Antioxidants
Subjects:
Online Access:https://www.mdpi.com/2076-3921/9/5/441