Factor VIII Fc Fusion Protein but not FVIII Drives Human Monocyte-Derived Dendritic Cell Activation via FcγRIIa

Factor VIII Fc Fusion Protein but not FVIII Drives Human Monocyte-Derived Dendritic Cell Activation via FcγRIIa

Abstract. This study compares the effect of recombinant Factor VIII Fc fusion protein (rFVIII-Fc) with recombinant FVIII (rFVIII) on monocyte-derived dendritic cells (moDC's). Cells treated with rFVIII-Fc showed morphological changes typical for cell activation, had a significant up-regulation...

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Bibliographic Details
Main Authors: Christoph Kannicht, Ilona Danßmann, Constanze Weilandt, Katja Derkow, Guido Kohla, Henriette Geyer
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000330

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http://journals.lww.com/10.1097/HS9.0000000000000330

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