Local delivery of minocycline-loaded PLGA nanoparticles from gelatin-coated neural implants attenuates acute brain tissue responses in mice

Local delivery of minocycline-loaded PLGA nanoparticles from gelatin-coated neural implants attenuates acute brain tissue responses in mice

Abstract Background Neural interfaces often elicit inflammatory responses and neuronal loss in the surrounding tissue which adversely affect the function and longevity of the implanted device. Minocycline, an anti-inflammatory pharmaceutics with neuroprotective properties, may be used for reducing t...

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Bibliographic Details
Main Authors: Alexander Dontsios Holmkvist, Johan Agorelius, Matilde Forni, Ulf J. Nilsson, Cecilia Eriksson Linsmeier, Jens Schouenborg
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Nanobiotechnology
Subjects:
Neural interface
Minocycline
Gelatin
PLGA
Nanoparticles
Drug-delivery-systems
Online Access:https://doi.org/10.1186/s12951-020-0585-9

Internet

https://doi.org/10.1186/s12951-020-0585-9

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