Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces an inflammatory phenotype.

Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces an inflammatory phenotype.

Mechanical loading of tendon cells results in an upregulation of mechanotransduction signaling pathways, cell-matrix adhesion and collagen synthesis, but whether unloading removes these responses is unclear. We investigated the response to tension release, with regard to matrix proteins, pro-inflamm...

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Bibliographic Details
Main Authors: Monika L Bayer, Peter Schjerling, Andreas Herchenhan, Cedric Zeltz, Katja M Heinemeier, Lise Christensen, Michael Krogsgaard, Donald Gullberg, Michael Kjaer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897642?pdf=render

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http://europepmc.org/articles/PMC3897642?pdf=render

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