EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: potential role of free fatty acid receptor 4

EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: potential role of free fatty acid receptor 4

Heart failure with preserved ejection fraction (HFpEF) is half of all HF, but standard HF therapies are ineffective. Diastolic dysfunction, often secondary to interstitial fibrosis, is common in HFpEF. Previously, we found that supra-physiologic levels of ω3-PUFAs produced by 12 weeks of ω3-dietary...

Full description

Bibliographic Details
Main Authors: Julie A. Eclov, Qingwen Qian, Rebecca Redetzke, Quanhai Chen, Steven C. Wu, Chastity L. Healy, Steven B. Ortmeier, Erin Harmon, Gregory C. Shearer, Timothy D. O'Connell
Format: Article
Language:English
Published: Elsevier 2015-12-01
Series:Journal of Lipid Research
Subjects:
eicosapentaenoic acid
docosahexaenoic acid
fibroblast
transverse aortic constriction
omega-3 polyunsaturated fatty acids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520309494

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520309494

Similar Items