Inhibitors of BMP‐1/tolloid‐like proteinases: efficacy, selectivity and cellular toxicity

Inhibitors of BMP‐1/tolloid‐like proteinases: efficacy, selectivity and cellular toxicity

BMP‐1/tolloid‐like proteinases belong to the astacin family of human metalloproteinases, together with meprins and ovastacin. They represent promising targets to treat or prevent a wide range of diseases such as fibrotic disorders or cancer. However, the study of their pathophysiological roles is st...

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Bibliographic Details
Main Authors: Maya Talantikite, Pascaline Lécorché, Fabrice Beau, Odile Damour, Christoph Becker‐Pauly, Wen‐Bin Ho, Vincent Dive, Sandrine Vadon‐Le Goff, Catherine Moali
Format: Article
Language:English
Published: Wiley 2018-12-01
Series:FEBS Open Bio
Subjects:
astacin
cornea
extracellular matrix
fibrotic disorders
metalloproteinase
protease inhibition
Online Access:https://doi.org/10.1002/2211-5463.12540

Internet

https://doi.org/10.1002/2211-5463.12540

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