Preclinical Evaluation of a Lead Specific Chelator (PSC) Conjugated to Radiopeptides for <sup>203</sup>Pb and <sup>212</sup>Pb-Based Theranostics

Preclinical Evaluation of a Lead Specific Chelator (PSC) Conjugated to Radiopeptides for <sup>203</sup>Pb and <sup>212</sup>Pb-Based Theranostics

<sup>203</sup>Pb and <sup>212</sup>Pb have emerged as promising theranostic isotopes for image-guided α-particle radionuclide therapy for cancers. Here, we report a cyclen-based Pb specific chelator (PSC) that is conjugated to tyr<sup>3</sup>-octreotide via a PEG&...

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Bibliographic Details
Main Authors: Mengshi Li, Nicholas J. Baumhover, Dijie Liu, Brianna S. Cagle, Frédéric Boschetti, Guillaume Paulin, Dongyoul Lee, Zhiming Dai, Ephraim R. Obot, Brenna M. Marks, Ibrahim Okeil, Edwin A. Sagastume, Moustafa Gabr, F. Christopher Pigge, Frances L. Johnson, Michael K. Schultz
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
Lead-212
Bismuth-212
Lead-203
chelators
stability
theranostics
Online Access:https://www.mdpi.com/1999-4923/15/2/414

Internet

https://www.mdpi.com/1999-4923/15/2/414

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