iGEM as a human iPS cell-based global epigenetic modulation detection assay provides throughput characterization of chemicals affecting DNA methylation

iGEM as a human iPS cell-based global epigenetic modulation detection assay provides throughput characterization of chemicals affecting DNA methylation

Abstract Chemical-induced dysregulation of DNA methylation during the fetal period is known to contribute to developmental disorders or increase the risk of certain diseases later in life. In this study, we developed an iGEM (iPS cell-based global epigenetic modulation) detection assay using human i...

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Bibliographic Details
Main Authors: Satoshi Otsuka, Xian-Yang Qin, Wenlong Wang, Tomohiro Ito, Hiroko Nansai, Kuniya Abe, Wataru Fujibuchi, Yoichi Nakao, Hideko Sone
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-33729-4

Internet

https://doi.org/10.1038/s41598-023-33729-4

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