Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer's Disease

Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer's Disease

The therapeutic potential of ultramicronized palmitoylethanolamide (um-PEA) was investigated in young (6-month-old) and adult (12-month-old) 3 × Tg-AD mice, which received um-PEA for 3 months via a subcutaneous delivery system. Mitochondrial bioenergetics, ATP homeostasis, and magnetic resonance ima...

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Bibliographic Details
Main Authors: Francesco Bellanti, Vidyasagar Naik Bukke, Archana Moola, Rosanna Villani, Caterina Scuderi, Luca Steardo, Gianmauro Palombelli, Rossella Canese, Sarah Beggiato, Mario Altamura, Gianluigi Vendemiale, Gaetano Serviddio, Tommaso Cassano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
glutamate
mitochondria
hippocampus
frontal cortex
microdialysis
Alzheimer's disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.890855/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.890855/full

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