Reprogramming Macrophage Polarization, Depleting ROS by Astaxanthin and Thioketal‐Containing Polymers Delivering Rapamycin for Osteoarthritis Treatment

Reprogramming Macrophage Polarization, Depleting ROS by Astaxanthin and Thioketal‐Containing Polymers Delivering Rapamycin for Osteoarthritis Treatment

Abstract Osteoarthritis (OA) is a chronic joint disease characterized by synovitis and joint cartilage destruction. The severity of OA is highly associated with the imbalance between M1 and M2 synovial macrophages. In this study, a novel strategy is designed to modulate macrophage polarization by re...

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Bibliographic Details
Main Authors: Huiyun Li, Yusong Yuan, Lingpu Zhang, Chun Xu, Hailin Xu, Zhiwei Chen
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Advanced Science
Subjects:
Astaxanthin
macrophage polarization
osteoarthritis
rapamycin
thioketal
Online Access:https://doi.org/10.1002/advs.202305363

Internet

https://doi.org/10.1002/advs.202305363

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