Involvement of the TNF-α/SATB2 axis in the induced apoptosis and inhibited autophagy of osteoblasts by the antipsychotic Risperidone

Involvement of the TNF-α/SATB2 axis in the induced apoptosis and inhibited autophagy of osteoblasts by the antipsychotic Risperidone

Abstract Background Risperidone, an atypical antipsychotic, impedes serotonin and dopamine receptor systems. Meanwhile, tumor necrosis factor-α (TNF-α) is known to participate in regulating osteoblast functions. Consequently, the current study aimed to investigate whether the influences of Risperido...

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Bibliographic Details
Main Authors: Shuyao Zhang, Wei He, Aiguo Li, Chengkuan Zhao, Yun Chen, Chengcheng Xu, Qiuzhen Zhang, Danling Zheng, Meini Chen, Haixiong Miao, Yihui Huang
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Molecular Medicine
Subjects:
Risperidone
Tumor necrosis factor-α
SATB2
Osteogenic differentiation
Differentiation
Autophagy
Online Access:https://doi.org/10.1186/s10020-022-00466-9

Internet

https://doi.org/10.1186/s10020-022-00466-9

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