Excitatory and inhibitory D-serine binding to the NMDA receptor

Excitatory and inhibitory D-serine binding to the NMDA receptor

N-methyl-D-aspartate receptors (NMDARs) uniquely require binding of two different neurotransmitter agonists for synaptic transmission. D-serine and glycine bind to one subunit, GluN1, while glutamate binds to the other, GluN2. These agonists bind to the receptor’s bi-lobed ligand-binding domains (LB...

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Bibliographic Details
Main Authors: Remy A Yovanno, Tsung Han Chou, Sarah J Brantley, Hiro Furukawa, Albert Y Lau
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
NMDA receptor
glutamate receptor
ligand binding
molecular dynamics
electrophysiology
Online Access:https://elifesciences.org/articles/77645

Internet

https://elifesciences.org/articles/77645

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