Development and Optimization of Chromosomally-Integrated Fluorescent Mycobacterium tuberculosis Reporter Constructs

Development and Optimization of Chromosomally-Integrated Fluorescent Mycobacterium tuberculosis Reporter Constructs

Mycobacterium tuberculosis resides in the lungs in various lesion types with unique microenvironmental conditions. This diversity is in line with heterogeneous disease progression and divergent drug efficiency. Fluorescent reporter strains can be used to decipher the micromilieu and to guide future...

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Bibliographic Details
Main Authors: Katharina Kolbe, Alice C. Bell, Gareth A. Prosser, Maike Assmann, Hee-Jeong Yang, He Eun Forbes, Sophia Gallucci, Katrin D. Mayer-Barber, Helena I. Boshoff, Clifton E. Barry III
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Microbiology
Subjects:
Mycobacterium tuberculosis
fluorescent protein
reporter strain
riboswitch
pH
magnesium
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.591866/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2020.591866/full

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