Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.

Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance.

OBJECTIVE: Diet-induced obesity (DIO) leads to an accumulation of intra-myocardial lipid metabolites implicated in causing cardiac insulin resistance and contractile dysfunction. One such metabolite is ceramide, and our aim was to determine the effects of inhibiting de novo ceramide synthesis on car...

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Bibliographic Details
Main Authors: John R Ussher, Clifford D L Folmes, Wendy Keung, Natasha Fillmore, Jagdip S Jaswal, Virgilio J Cadete, Donna L Beker, Victoria H Lam, Liyan Zhang, Gary D Lopaschuk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3358297?pdf=render

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http://europepmc.org/articles/PMC3358297?pdf=render

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