Local environment in biomolecular condensates modulates enzymatic activity across length scales

Abstract The mechanisms that underlie the regulation of enzymatic reactions by biomolecular condensates and how they scale with compartment size remain poorly understood. Here we use intrinsically disordered domains as building blocks to generate programmable enzymatic condensates of NADH-oxidase (N...

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Bibliographic Details
Main Authors: Marcos Gil-Garcia, Ana I. Benítez-Mateos, Marcell Papp, Florence Stoffel, Chiara Morelli, Karl Normak, Katarzyna Makasewicz, Lenka Faltova, Francesca Paradisi, Paolo Arosio
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-47435-w