Discovery of Oxazol-2-amine Derivatives as Potent Novel FLT3 Inhibitors

Discovery of Oxazol-2-amine Derivatives as Potent Novel FLT3 Inhibitors

Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) is the most common mutation in patients with acute myeloid leukemia (AML). FLT3-ITD<sup>+</sup> induces constitutive activation of FLT3, causing an abnormally rapid proliferation of cancer cells. In this study, we ide...

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Bibliographic Details
Main Authors: Hyo Jeong Kim, Hwani Ryu, Jie-Young Song, Sang-Gu Hwang, Shivakumar S. Jalde, Hyun-Kyung Choi, Jiyeon Ahn
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
FLT3 inhibitor
acute myeloid leukemia
DNA damage repair
combination therapy
PARP1 inhibitor
Online Access:https://www.mdpi.com/1420-3049/25/21/5154

Internet

https://www.mdpi.com/1420-3049/25/21/5154

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