IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

The role of IFI16 as a DNA sensor is highly controversial. With support from aNature Communications back-to-back publication from Jønsson et al., the authors here provide functional evidence that IFI16 is involved in DNA sensing via the cGAS-STING pathway in human keratinocytes.

Bibliographic Details
Main Authors: Jessica F. Almine, Craig A. J. O’Hare, Gillian Dunphy, Ismar R. Haga, Rangeetha J. Naik, Abdelmadjid Atrih, Dympna J. Connolly, Jordan Taylor, Ian R. Kelsall, Andrew G. Bowie, Philippa M. Beard, Leonie Unterholzner
Format: Article
Language:English
Published: Nature Portfolio 2017-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14392

Internet

https://doi.org/10.1038/ncomms14392

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