Receptor Binding Domains of TcdB from <i>Clostridioides difficile</i> for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive

Receptor Binding Domains of TcdB from <i>Clostridioides difficile</i> for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive

Toxin B (TcdB) produced by <i>Clostridioides difficile</i> is a main pathogenicity factor that affects a variety of different cell types within the colonic mucosa. TcdB is known to utilize frizzled-1,2,7 and chondroitin sulfate proteoglycan-4 (CSPG4) as protein receptors. By using human...

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Bibliographic Details
Main Authors: Daniel Henkel, Helma Tatge, Dennis Schöttelndreier, Liang Tao, Min Dong, Ralf Gerhard
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Toxins
Subjects:
<i>Clostridioides difficile</i>
glucosyltransferase
receptor binding
Online Access:https://www.mdpi.com/2072-6651/12/12/736

Internet

https://www.mdpi.com/2072-6651/12/12/736

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