Decreased angiotensin receptor 1 expression in ± AT1 Knockout mice testis results in male infertility and GnRH reduction

Decreased angiotensin receptor 1 expression in ± AT1 Knockout mice testis results in male infertility and GnRH reduction

Abstract Background This study aimed to detect the effect of angiotensin receptor 1 (AT1) knock out (KO) on spermatogenesis and hypothalamic-pituitary–gonadal (HPG) axis hormone expression. Methods Normal C57BL/6 male mice were used as control group or treated with angiotensin receptor blocker, in a...

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Bibliographic Details
Main Authors: Fangfang Zhao, Yun Zou, Hui Li, Yaheng Zhang, Xuele Liu, Xuehao Zhao, Xinyi Wu, Wenyi Fei, Ziling Xu, Xuejun Yang
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Reproductive Biology and Endocrinology
Subjects:
Angiotensin receptor 1
Male infertility
 ± AT1KO mice
Testis
Hypothalamic-pituitary–gonadal (HPG) axis
Online Access:https://doi.org/10.1186/s12958-021-00805-1

Internet

https://doi.org/10.1186/s12958-021-00805-1

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