Improved Glycaemic Control and Nephroprotective Effects of Empagliflozin and Paricalcitol Co-Therapy in Mice with Type 2 Diabetes Mellitus

Improved Glycaemic Control and Nephroprotective Effects of Empagliflozin and Paricalcitol Co-Therapy in Mice with Type 2 Diabetes Mellitus

Herein, we measured the antidiabetic and nephroprotective effects of the sodium–glucose cotransporter-2 inhibitor (empagliflozin; SGLT2i) and synthetic active vitamin D (paricalcitol; Pcal) mono- and co-therapy against diabetic nephropathy (DN). Fifty mice were assigned into negative (NC) and positi...

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Main Authors: Abdulrahman Mujalli, Wesam F. Farrash, Ahmad A. Obaid, Anmar A. Khan, Riyad A. Almaimani, Shakir Idris, Mohamed E. Elzubier, Elshiekh Babiker A. Khidir, Akhmed Aslam, Faisal Minshawi, Mohammad A. Alobaidy, Adel B. Alharbi, Hussain A. Almasmoum, Mazen Ghaith, Khalid Alqethami, Bassem Refaat
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
SGLT2 inhibitor
adipokines
INOS
KIM-1
NGAL
TGF-β
Online Access:https://www.mdpi.com/1422-0067/24/24/17380

Internet

https://www.mdpi.com/1422-0067/24/24/17380

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