Bio-behavioural changes in treatment-resistant socially isolated FSL rats show variable or improved response to combined fluoxetine-olanzapine versus olanzapine treatment

Bio-behavioural changes in treatment-resistant socially isolated FSL rats show variable or improved response to combined fluoxetine-olanzapine versus olanzapine treatment

Background: Exposure of Flinders Sensitive Line (FSL) rats to post-weaning social isolation rearing (SIR) causes depressive- and social anxiety-like symptoms resistant to, or worsened by, fluoxetine. SIR typically presents with psychotic-like symptoms, while the paradoxical response to fluoxetine su...

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Bibliographic Details
Main Authors: K. Mncube, B.H. Harvey
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:IBRO Neuroscience Reports
Subjects:
Inflammation
Fluoxetine plus olanzapine
Animal model
Social anxiety
Psychotic depression
Bipolar disorder, dual hit
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242122000616

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http://www.sciencedirect.com/science/article/pii/S2667242122000616

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