Dysregulation of neuroprotective astrocytes, a spectrum of microglial activation states, and altered hippocampal neurogenesis are revealed by single-cell RNA sequencing in prion disease

Dysregulation of neuroprotective astrocytes, a spectrum of microglial activation states, and altered hippocampal neurogenesis are revealed by single-cell RNA sequencing in prion disease

Abstract Prion diseases are neurodegenerative disorders with long asymptomatic incubation periods, followed by a rapid progression of cognitive and functional decline culminating in death. The complexity of intercellular interactions in the brain is challenging to unravel and the basis of disease pa...

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Bibliographic Details
Main Authors: Jessy A. Slota, Babu V. Sajesh, Kathy F. Frost, Sarah J. Medina, Stephanie A. Booth
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Acta Neuropathologica Communications
Subjects:
Prion disease
Neurodegeneration
Pathogenesis
Single-cell RNAseq
Systems biology
Microglia
Online Access:https://doi.org/10.1186/s40478-022-01450-4

Internet

https://doi.org/10.1186/s40478-022-01450-4

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