Integrative whole-genome and transcriptome analysis of HER2-amplified metastatic breast cancer

Abstract Background In breast cancer, the advent of anti-HER2 therapies has made HER2+ tumors a highly relevant subgroup. However, the exact characteristics which prohibit clinical response to anti-HER2 therapies and drive disease progression are not yet fully known. Integrative whole-genome and tra...

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Bibliographic Details
Main Authors: Noortje Verschoor, Marcel Smid, Agnes Jager, Stefan Sleijfer, Saskia M. Wilting, John W. M. Martens
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Breast Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13058-023-01743-z