High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth

High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth

Abstract Background Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs for clinical use. Here, based on our previous study of sterol O-acyltransferase 1 (SOAT1) in hepatocelluar carcinoma, we sought to screen an effecti...

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Bibliographic Details
Main Authors: Zhihua Wang, Miaomiao Wang, Mengxin Zhang, Kaikun Xu, Xinshuai Zhang, Yi Xie, Yiming Zhang, Cheng Chang, Xiaolu Li, Aihua Sun, Fuchu He
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Medicine
Subjects:
Cholesterol metabolism
Hepatocelluar carcinoma
SOAT1
Nilotinib
Antitumor mechanism
Online Access:https://doi.org/10.1186/s12916-022-02436-8

Internet

https://doi.org/10.1186/s12916-022-02436-8

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