AAV process intensification by perfusion bioreaction and integrated clarification

AAV process intensification by perfusion bioreaction and integrated clarification

Adeno-associated viruses (AAVs) demand for clinical trials and approved therapeutic applications is increasing due to this vector’s overall success and potential. The high doses associated with administration strategies challenges bioprocess engineers to develop more efficient technologies and innov...

Full description

Bibliographic Details
Main Authors: João P. Mendes, Bárbara Fernandes, Earl Pineda, Shashi Kudugunti, Mike Bransby, René Gantier, Cristina Peixoto, Paula M. Alves, António Roldão, Ricardo J. S. Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
adeno-associated virus
alternating tangential flow
perfusion
gene therapy
integrated manufacturing
tangential flow depth filtration
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.1020174/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2022.1020174/full

Similar Items